MOTS-c

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA-c) is a mitochondrial-derived peptide consisting of 16 amino acids, encoded within the 12S ribosomal RNA gene of the mitochondrial genome. Its discovery represented a significant advancement in mitochondrial biology research, establishing that mitochondria produce bioactive peptides capable of regulating systemic metabolic function. It is one of the most rapidly emerging research peptides available to Canadian researchers today.

Researchers have investigated MOTS-c across a broad range of in vitro and in vivo models, with published studies exploring its role in AMPK pathway activation, glucose metabolism regulation, and mitochondrial biogenesis. Of particular interest to researchers is MOTS-c’s apparent ability to translocate to the nucleus in response to metabolic stress, where it has been shown to regulate nuclear gene expression related to oxidative stress response and metabolic adaptation. Published research has also examined its interactions with insulin sensitivity pathways, skeletal muscle metabolism, and age-related metabolic decline models, with researchers noting significant attenuation of metabolic dysfunction in preclinical aging models.

MOTS-c is consistently selected by Canadian researchers studying mitochondrial biology, metabolic pathway regulation, and longevity-related research models, and represents one of the most promising emerging compounds in the mitochondrial peptide research space.

Ambros Labs supplies MOTS-c to qualified researchers across Canada from our Canadian inventory. Every batch is independently tested by a third-party Canadian laboratory using HPLC and mass spectrometry, with verifiable Certificates of Analysis available for every batch. All orders ship same-day from Canada with full chain of custody documentation.

For research use only. Not for human or veterinary use. For use by qualified researchers in appropriate laboratory settings only.

CAS Number: 1627580-64-6

Molecular Weight (g/moL): 2174.6

Molecular Formula: C101H152N28O22S2

Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

Format: White Lyophilized Powder

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